Causes for low positive predictive values of CD4 counts for antiretroviral treatment failure
نویسندگان
چکیده
منابع مشابه
comparison of zoe and vitapex for canal treatment of necrotic primary teeth
چکیده ندارد.
15 صفحه اولUtility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
BACKGROUND Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alternative monitoring strategy has not been rigorously assessed. METHODS In this study, we used a novel modelling approach that accounted for all CD4 cell count and VL values meas...
متن کاملAntiretroviral therapy suppressed participants with low CD4+ T-cell counts segregate according to opposite immunological phenotypes
BACKGROUND The failure to increase CD4 T-cell counts in some antiretroviral therapy suppressed participants (immunodiscordance) has been related to perturbed CD4 T-cell homeostasis and impacts clinical evolution. METHODS We evaluated different definitions of immunodiscordance based on CD4 T-cell counts (cutoff) or CD4 T-cell increases from nadir value (ΔCD4) using supervised random forest cla...
متن کاملAntiretroviral Treatment Cohort Analysis Using Time-Updated CD4 Counts: Assessment of Bias with Different Analytic Methods
BACKGROUND Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events. The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported. METHODS This study examined the effect of three different estimation methods: assuming i) a...
متن کاملA comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts.
OBJECTIVE To compare the immunological response to highly active antiretroviral therapy (HAART) in treatment-naive patients with a baseline CD4 count of <200 cells/mm(3). DESIGN AND METHODS We identified treatment-naive human immunodeficiency virus (HIV-1)-infected individuals who had commenced HAART since 1996 and who had a starting CD4 count of <200 cells/mm(3). Immunological success was de...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2008
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2008.02.002